GSK3A

Across TCGA patient cohorts, GSK3A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,800 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GSK3A-associated proteins across cancer lineages are PAFAH1B3, SAE1, and UBA2. Each is linked with GSK3A in more than 6 cancer types. Because this analysis shows association rather than direction, both GSK3A-to-partner and partner-to-GSK3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSK3A versus PAFAH1B3 in OV, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3A→partner) and Y-score (partner→GSK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PAFAH1B3 →	+0.644	+0.655	<.001	.004	3	7
LSCC	SAE1 →	+0.318	+0.457	<.001	<.001	3	7
BRCA	UBA2 →	+0.276	+0.352	.002	.002	3	6
GBM	TRADD →	-0.382	-0.259	<.001	<.001	3	6
OV	PNKP →	+0.343	+0.587	<.001	<.001	3	6
BRCA	PPP5C →	+0.278	+0.448	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,800 associations by consensus.

GSK3A vs PAFAH1B3 — OV

Explore this scatter interactively →