GSK3A

Across TCGA patient cohorts, GSK3A protein abundance is significantly associated with the RNA expression of many other genes, with 5,102 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GSK3A-associated genes across cancer lineages are DMAC2, ZNF576, and DEDD2. Each is linked with GSK3A in more than 3 cancer types. Because this analysis shows association rather than direction, both GSK3A-to-partner and partner-to-GSK3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSK3A versus DMAC2 in OV, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3A→partner) and Y-score (partner→GSK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DMAC2 →	+0.482	+0.345	.002	<.001	2	4
OV	ZNF576 →	+0.363	+0.303	.001	.003	3	3
OV	DEDD2 →	+0.539	+0.326	<.001	<.001	3	3
LSCC	ERF →	+0.578	+0.257	<.001	<.001	3	2
OV	CBLN3 →	-0.615	-0.282	.001	.005	3	2
GBM	GABRA6 →	+0.105	+0.253	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,102 associations by consensus.

GSK3A vs DMAC2 — OV

Explore this scatter interactively →