GSK3A

Across TCGA patient cohorts, GSK3A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSK3A-associated genes across cancer lineages are EGFR_pY1068, GATA6, and MEK1. Each is linked with GSK3A in more than 1 cancer types. Because this analysis shows association rather than direction, both GSK3A-to-partner and partner-to-GSK3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GSK3A-low versus GSK3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3A→partner) and Y-score (partner→GSK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.214	-1.502	.020	.030	3	2
UCEC	GATA6 →	-0.144	-1.670	.014	.022	3	2
UCEC	MEK1 →	+0.376	+2.321	.005	.005	3	2
UCEC	Akt_pT308 →	+0.546	+2.115	.018	.016	3	2
UCEC	ATM →	-0.488	-3.687	.003	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.884	+3.926	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by GSK3A expression — UCEC

Explore this box plot interactively →