GSK3A

Across TCGA cell cohorts, GSK3A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSK3A-associated genes across cancer lineages are FAM205A, DCD, and OR6J1. Each is linked with GSK3A in more than 1 cancer types. Because this analysis shows association rather than direction, both GSK3A-to-partner and partner-to-GSK3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by GSK3A-low versus GSK3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3A→partner) and Y-score (partner→GSK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
BLOOD_Lymphoma	DCD →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR6J1 →	+0.006	+5.643	<.001	.002	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.018	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TDRD15 →	+0.435	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TRPM3 →	+0.053	+4.295	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM205A by GSK3A expression — LARGE_INTESTINE

Explore this box plot interactively →