GSG1

Across TCGA patient cohorts, GSG1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSG1-associated genes across cancer lineages are EGFR_pY1068, ACVRL1, and PKC-b-II_pS660. Each is linked with GSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSG1-to-partner and partner-to-GSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GSG1-low versus GSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSG1→partner) and Y-score (partner→GSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.317	-2.906	.002	.001	3	2
UCEC	ACVRL1 →	-0.130	-2.565	.024	.010	3	2
UCEC	PKC-b-II_pS660 →	-0.310	-2.222	.008	.011	3	2
UCEC	14-3-3_beta →	-0.088	-2.973	.040	.035	3	1
UCEC	eEF2 →	+0.431	+3.321	.004	.010	3	1
UCEC	eIF4G →	+0.318	+2.321	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by GSG1 expression — UCEC

Explore this box plot interactively →