GSE1

Across TCGA pan-cancer cohorts, GSE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GSE1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GSE1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GSE1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where GSE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.446	0.831	.003	25	view →
HNSC	DFS	Median	All	0.860	0.317	.018	6	view →
UCEC	DFS	Median	III,IV	0.905	0.494	.044	4	view →
LUAD	DFS	Quartile	II,III,IV	0.783	0.212	.018	2	view →
LSCC	DFS	Tertile	II,III,IV	0.841	0.587	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GSE1–PDAC (OS)

Open the PDAC breakdown →