GSE1

Across TCGA patient cohorts, GSE1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSE1-associated genes across cancer lineages are HER3_pY1289, MSH2, and MSH6. Each is linked with GSE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSE1-to-partner and partner-to-GSE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by GSE1-low versus GSE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSE1→partner) and Y-score (partner→GSE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.067	+2.019	.018	.017	3	2
UCEC	MSH2 →	-0.355	-3.558	<.001	.002	3	2
UCEC	MSH6 →	-0.492	-3.169	<.001	<.001	3	2
UCEC	Notch1 →	+0.109	+1.495	.019	.034	3	2
UCEC	Annexin-1 →	+0.467	+1.720	.007	.025	3	2
UCEC	Shc_pY317 →	-0.126	-1.392	.011	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

HER3_pY1289 by GSE1 expression — UCEC

Explore this box plot interactively →