GSDME

Across TCGA cell cohorts, GSDME RNA expression is significantly associated with the go_rna of many other GO terms, with 5,661 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GSDME-associated GO terms across cancer lineages are PML body organization, Regulation of cell-matrix adhesion, and Negative regulation of cell-matrix adhesion. Each is linked with GSDME in more than 11 cancer types. Because this analysis shows association rather than direction, both GSDME-to-partner and partner-to-GSDME results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by GSDME-low versus GSDME-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDME→partner) and Y-score (partner→GSDME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PML body organization →	+0.232	+2.877	.001	.003	3	12
BONE	Regulation of cell-matrix adhesion →	+0.114	+2.280	<.001	<.001	3	11
BONE	Negative regulation of cell-matrix adhesion →	+0.152	+2.272	<.001	<.001	3	11
BONE	Negative regulation of dendritic cell apoptotic process →	+1.324	+2.336	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Transport of virus →	+0.267	+3.405	<.001	.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of fibroblast proliferation →	+0.157	+2.916	.005	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,661 associations by consensus.

PML body organization by GSDME expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →