GSDME

Across TCGA cell cohorts, GSDME mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSDME-associated genes across cancer lineages are LACRT, PRAMEF14, and MYH4. Each is linked with GSDME in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDME-to-partner and partner-to-GSDME results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACRT grouped by GSDME-low versus GSDME-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDME→partner) and Y-score (partner→GSDME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LACRT →	+0.145	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRAMEF14 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	MYH4 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPANXN2 →	+0.010	+5.266	<.001	.001	3	1
LARGE_INTESTINE	RSPH6A →	+0.138	+3.466	<.001	.005	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.387	+3.620	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LACRT by GSDME expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →