GSDMC

Across TCGA patient cohorts, GSDMC protein abundance is significantly associated with the RNA expression of many other genes, with 9,162 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GSDMC-associated genes across cancer lineages are POLI, CCP110, and LARP1B. Each is linked with GSDMC in more than 2 cancer types. Because this analysis shows association rather than direction, both GSDMC-to-partner and partner-to-GSDMC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMC versus POLI in BRCA, with a Pearson correlation of -0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMC→partner) and Y-score (partner→GSDMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLI →	-0.970	-0.875	<.001	.003	3	3
BRCA	CCP110 →	-0.914	-0.970	.003	<.001	3	3
BRCA	LARP1B →	-0.578	-1.250	.005	<.001	3	3
BRCA	BCL2 →	-2.085	-1.188	.005	.002	3	3
HNSC	ZBED2 →	+1.422	+1.013	<.001	<.001	3	3
HNSC	GUSBP2 →	-0.830	-1.010	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,162 associations by consensus.

GSDMC vs POLI — BRCA

Explore this scatter interactively →