GSDMC

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GSDMC protein abundance is significantly associated with the protein abundance of many other proteins, with 11,504 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GSDMC-associated proteins across cancer lineages are PTPN12_S449, ARHGEF1, and FGD6_S515. Each is linked with GSDMC in more than 2 cancer types. Because this analysis shows association rather than direction, both GSDMC-to-partner and partner-to-GSDMC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMC versus PTPN12_S449 in BRCA, with a Pearson correlation of 0.99.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMC→partner) and Y-score (partner→GSDMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAPTPN12_S449 →+0.793+1.203<.001.00133
BRCAARHGEF1 →+0.321+1.058<.001<.00132
LSCCFGD6_S515 →+0.472+1.045.001<.00132
LSCCFIP1L1 →-0.319-1.525<.001<.00132
HNSCFLRT3 →+0.687+0.931<.001<.00132
HNSCFN3K →-0.568-0.933<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 11,504 associations by consensus.

GSDMC vs PTPN12_S449 — BRCA

Per-sample scatter of GSDMC vs PTPN12_S449 in BRCA (Pearson r = 0.99).

Explore this scatter interactively →

Exploration