GSDMC

Across TCGA patient cohorts, GSDMC mutation is significantly associated with the RNA expression of many other genes, with 2,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSDMC-associated genes across cancer lineages are BPNT1, SF3B5, and RRM2. Each is linked with GSDMC in more than 2 cancer types. Because this analysis shows association rather than direction, both GSDMC-to-partner and partner-to-GSDMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPNT1 grouped by GSDMC-low versus GSDMC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMC→partner) and Y-score (partner→GSDMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BPNT1 →	+0.459	+3.642	.009	.001	3	3
UCEC	SF3B5 →	+0.393	+2.749	.004	.003	3	3
UCEC	RRM2 →	+0.837	+2.736	<.001	<.001	3	3
UCEC	SARS1 →	+0.505	+2.210	<.001	.001	3	3
UCEC	ENO1 →	+0.496	+3.716	.006	<.001	3	3
BRCA	BCRP9 →	+0.640	+4.220	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,469 associations by consensus.

BPNT1 by GSDMC expression — UCEC

Explore this box plot interactively →