GSDMC

Across TCGA patient cohorts, GSDMC mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSDMC-associated genes across cancer lineages are PDCD4, FASN, and Notch1. Each is linked with GSDMC in more than 2 cancer types. Because this analysis shows association rather than direction, both GSDMC-to-partner and partner-to-GSDMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GSDMC-low versus GSDMC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMC→partner) and Y-score (partner→GSDMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.545	-1.700	.006	.044	3	3
SKCM	FASN →	+0.507	+3.000	.016	.034	3	2
UCEC	Notch1 →	+0.259	+2.598	<.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.093	-2.321	.033	.034	3	2
UCEC	ASNS →	+0.502	+2.584	.001	.010	3	2
UCEC	c-Kit →	-0.210	-2.308	.033	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PDCD4 by GSDMC expression — UCEC

Explore this box plot interactively →