GSDMC

Across TCGA cell cohorts, GSDMC mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSDMC-associated genes across cancer lineages are 123829, Venetoclax, and AT7867. Each is linked with GSDMC in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDMC-to-partner and partner-to-GSDMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 123829 grouped by GSDMC-low versus GSDMC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMC→partner) and Y-score (partner→GSDMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	123829 →	+0.590	+2.871	.032	.021	3	1
LARGE_INTESTINE	Venetoclax →	+0.328	+2.777	.043	.038	3	1
LARGE_INTESTINE	AT7867 →	+0.565	+2.874	.012	.021	3	1
LARGE_INTESTINE	CD532 →	+0.395	+2.874	.039	.021	3	1
LARGE_INTESTINE	IWP-2 →	+0.277	+3.115	.027	.015	2	1
LARGE_INTESTINE	Oxaliplatin →	+0.497	+2.871	.048	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

123829 by GSDMC expression — LARGE_INTESTINE

Explore this box plot interactively →