GSDMB

Across TCGA pan-cancer cohorts, GSDMB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GSDMB data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GSDMB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GSDMB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where GSDMB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.706	0.434	.003	55	view →
LSCC	OS	Median	II,III,IV	0.517	0.896	<.001	11	view →
LUAD	OS	Median	II,III,IV	0.732	0.471	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GSDMB–PDAC (OS)

Open the PDAC breakdown →