GSDMB

Across TCGA patient cohorts, GSDMB RNA expression is significantly associated with the protein abundance of many other proteins, with 12,002 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GSDMB-associated proteins across cancer lineages are GRB7, ARFGAP3, and SEC63. Each is linked with GSDMB in more than 3 cancer types. Because this analysis shows association rather than direction, both GSDMB-to-partner and partner-to-GSDMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMB versus GRB7 in BRCA, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMB→partner) and Y-score (partner→GSDMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GRB7 →	+1.174	+1.571	<.001	<.001	3	4
UCEC	ARFGAP3 →	-0.409	-0.820	.001	.004	3	4
COAD	SEC63 →	-0.313	-0.903	<.001	<.001	3	4
LSCC	SLC12A4 →	-0.333	-0.475	<.001	<.001	3	4
HNSC	PYGL →	-0.420	-0.464	.004	.002	3	4
PDAC	OASL →	+0.501	+0.552	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,002 associations by consensus.

GSDMB vs GRB7 — BRCA

Explore this scatter interactively →