GSDMB

Across TCGA patient cohorts, GSDMB protein abundance is significantly associated with the RNA expression of many other genes, with 6,507 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GSDMB-associated genes across cancer lineages are RTP4, DDX60, and CARD16. Each is linked with GSDMB in more than 5 cancer types. Because this analysis shows association rather than direction, both GSDMB-to-partner and partner-to-GSDMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMB versus RTP4 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMB→partner) and Y-score (partner→GSDMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RTP4 →	+1.267	+1.056	.001	<.001	3	6
COAD	DDX60 →	+1.026	+0.596	<.001	.004	3	6
BRCA	CARD16 →	+1.003	+1.290	<.001	.001	3	6
COAD	CLINT1 →	+0.546	+0.559	<.001	<.001	3	5
LSCC	FKBP10 →	-1.069	-1.062	.001	<.001	3	5
CCRCC	TMPRSS3 →	+1.764	+1.002	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,507 associations by consensus.

GSDMB vs RTP4 — UCEC

Explore this scatter interactively →