GSDMB

Across TCGA patient cohorts, GSDMB mutation is significantly associated with the RNA expression of many other genes, with 734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSDMB-associated genes across cancer lineages are OR5AL2P, OIP5, and NUSAP1. Each is linked with GSDMB in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDMB-to-partner and partner-to-GSDMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AL2P grouped by GSDMB-low versus GSDMB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMB→partner) and Y-score (partner→GSDMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5AL2P →	+0.012	+4.225	<.001	.005	3	2
UCEC	OIP5 →	+0.911	+3.606	.002	.001	3	2
UCEC	NUSAP1 →	+0.832	+3.584	.007	.003	3	2
UCEC	KNL1 →	+0.786	+3.467	.002	.002	3	2
UCEC	CCNA2 →	+0.950	+3.595	.002	.001	3	2
UCEC	MKI67 →	+0.798	+3.606	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 734 associations by consensus.

OR5AL2P by GSDMB expression — SKCM

Explore this box plot interactively →