GSDMB

Across TCGA cell cohorts, GSDMB mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible GSDMB-associated genes across cancer lineages are SLC17A2, SMIM9, and OR1L3. Each is linked with GSDMB in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDMB-to-partner and partner-to-GSDMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by GSDMB-low versus GSDMB-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMB→partner) and Y-score (partner→GSDMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC17A2 →	+0.013	+5.000	<.001	.006	3	1
PANCREAS	SMIM9 →	+0.036	+5.614	<.001	.002	3	1
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SLC17A2 by GSDMB expression — PANCREAS

Explore this box plot interactively →