GSDMA

Across TCGA pan-cancer cohorts, GSDMA Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GSDMA data layer compared with 18 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher GSDMA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSDMA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THCA, PRAD, and ACC are the cancer types where GSDMA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.178	0.842	.010	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
UCEC	DFS	Median	All	1.000	0.628	.027	6	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	5	view →
GBM	DFS	Median	All	0.052	0.242	.011	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GSDMA–THCA (DFS)

Open the THCA breakdown →