GSDMA

Across TCGA pan-cancer cohorts, GSDMA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GSDMA data layer compared with 18 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GSDMA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GSDMA expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where GSDMA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.937	0.801	.018	9	view →
GBM	DFS	Tertile	All	0.923	0.430	.011	7	view →
CCRCC	DFS	Median	III,IV	0.275	0.856	.013	3	view →
LUAD	OS	Quartile	All	0.881	1.000	.024	1	view →
LSCC	OS	Quartile	III,IV	1.000	0.546	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GSDMA–HNSC (OS)

Open the HNSC breakdown →