GSDMA

Across TCGA patient cohorts, GSDMA mutation is significantly associated with the RNA expression of many other genes, with 2,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSDMA-associated genes across cancer lineages are UHRF1, ZNF833P, and RPL21P41. Each is linked with GSDMA in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDMA-to-partner and partner-to-GSDMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by GSDMA-low versus GSDMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMA→partner) and Y-score (partner→GSDMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.734	+2.233	.007	.006	3	2
CESC	ZNF833P →	+0.029	+3.411	.001	.009	3	2
CESC	RPL21P41 →	+0.127	+3.413	.008	.006	3	2
LUAD	PGBD4P5 →	+0.138	+5.631	<.001	.004	3	2
LUAD	LINC01742 →	+0.174	+5.279	<.001	.006	3	2
SKCM	SYNJ2BP-COX16 →	+0.285	+2.604	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

UHRF1 by GSDMA expression — UCEC

Explore this box plot interactively →