GSDMA

Across TCGA patient cohorts, GSDMA mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSDMA-associated genes across cancer lineages are STAT3_pY705, JNK_pT183_Y185, and C-Raf. Each is linked with GSDMA in more than 2 cancer types. Because this analysis shows association rather than direction, both GSDMA-to-partner and partner-to-GSDMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by GSDMA-low versus GSDMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMA→partner) and Y-score (partner→GSDMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.424	-2.459	<.001	.018	3	3
UCEC	JNK_pT183_Y185 →	-0.193	-1.986	.011	.032	3	2
UCEC	C-Raf →	+0.192	+2.000	.002	.032	3	2
SKCM	Cyclin-B1 →	+0.403	+2.700	.027	.006	3	2
UCEC	EGFR_pY1068 →	-0.310	-2.700	.006	.006	3	2
SKCM	mTOR →	+0.256	+2.700	.017	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

STAT3_pY705 by GSDMA expression — UCEC

Explore this box plot interactively →