GSDMA

Across TCGA cell cohorts, GSDMA RNA expression is significantly associated with the go_rna of many other GO terms, with 746 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSDMA-associated GO terms across cancer lineages are Regulation of cytokine-mediated signaling pathway, Macrophage colony-stimulating factor signaling pathway, and Regulation of neutrophil degranulation. Each is linked with GSDMA in more than 3 cancer types. Because this analysis shows association rather than direction, both GSDMA-to-partner and partner-to-GSDMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytokine-mediated signaling pathway grouped by GSDMA-low versus GSDMA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMA→partner) and Y-score (partner→GSDMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of cytokine-mediated signaling pathway →	+0.049	+0.748	<.001	.009	3	4
LUNG_SCLC	Macrophage colony-stimulating factor signaling pathway →	+0.720	+0.641	.001	.007	3	4
LUNG_SCLC	Regulation of neutrophil degranulation →	+0.923	+0.671	.003	.005	3	4
LUNG_SCLC	Sensory perception of salty taste →	+0.899	+0.662	.001	.005	3	4
LARGE_INTESTINE	Positive regulation of sodium ion transport →	+0.120	+0.974	.005	.009	3	4
LARGE_INTESTINE	Potassium ion import across plasma membrane →	+0.160	+1.057	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 746 associations by consensus.

Regulation of cytokine-mediated signaling pathway by GSDMA expression — LUNG_SCLC

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