GSDMA

Across TCGA cell cohorts, GSDMA mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSDMA-associated genes across cancer lineages are GML, ASZ1, and CALHM4. Each is linked with GSDMA in more than 1 cancer types. Because this analysis shows association rather than direction, both GSDMA-to-partner and partner-to-GSDMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by GSDMA-low versus GSDMA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMA→partner) and Y-score (partner→GSDMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.067	+4.152	.001	.009	3	1
BLOOD_Leukemia	ASZ1 →	+0.119	+4.152	.001	.009	3	1
BLOOD_Leukemia	CALHM4 →	+0.048	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR1N2 →	+0.039	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR56A4 →	+0.006	+4.874	.009	.002	3	1
BLOOD_Leukemia	TSSK1B →	+0.019	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GML by GSDMA expression — BLOOD_Leukemia

Explore this box plot interactively →