Across TCGA patient cohorts, GRXCR2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRXCR2-associated genes across cancer lineages are Heregulin, HSP70, and JNK2. Each is linked with GRXCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRXCR2-to-partner and partner-to-GRXCR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRXCR2→partner) and Y-score (partner→GRXCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.168	-3.169	.006	.019	3	1
UCEC	HSP70 →	-0.435	-2.321	.031	.035	3	1
UCEC	JNK2 →	+0.209	+2.321	.036	.035	2	2
UCEC	p70-S6K_pT389 →	-0.227	-2.990	.017	.036	3	1
UCEC	P-Cadherin →	-0.208	-3.169	.004	.018	3	1
UCEC	PRAS40_pT246 →	+0.211	+2.335	.014	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

GRXCR2 survival (RNA) · tumor vs normal (RNA) · all GRXCR2 data types