Across TCGA patient cohorts, GRXCR1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRXCR1-associated genes across cancer lineages are ATM, Caspase-8, and YAP_pS127. Each is linked with GRXCR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRXCR1-to-partner and partner-to-GRXCR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRXCR1→partner) and Y-score (partner→GRXCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.351	-2.446	.035	.018	3	3
UCEC	Caspase-8 →	-0.218	-3.432	.018	.005	3	2
SKCM	YAP_pS127 →	-0.361	-2.169	.006	.003	3	2
UCEC	14-3-3_beta →	-0.094	-1.673	.011	.040	3	1
UCEC	JNK2 →	+0.230	+2.247	.001	.001	3	1
UCEC	MEK1 →	+0.455	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

GRXCR1 survival (RNA) · tumor vs normal (RNA) · all GRXCR1 data types