GRTP1

Across TCGA patient cohorts, GRTP1 mutation is significantly associated with the RNA expression of many other genes, with 1,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRTP1-associated genes across cancer lineages are MIR4286, ERGIC1, and SRSF4. Each is linked with GRTP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRTP1-to-partner and partner-to-GRTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4286 grouped by GRTP1-low versus GRTP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRTP1→partner) and Y-score (partner→GRTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4286 →	+0.530	+5.683	<.001	.004	3	2
UCEC	ERGIC1 →	+0.793	+3.906	<.001	<.001	3	2
UCEC	SRSF4 →	+0.425	+2.807	.003	.003	3	2
UCEC	TMED5 →	+0.652	+2.201	.003	.009	3	2
UCEC	HNRNPR →	+0.721	+2.839	.001	.001	3	2
UCEC	COPB1 →	+0.512	+3.475	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,409 associations by consensus.

MIR4286 by GRTP1 expression — BRCA

Explore this box plot interactively →