GRSF1

Across TCGA patient cohorts, GRSF1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRSF1-associated genes across cancer lineages are TFRC, ASNS, and c-Jun_pS73. Each is linked with GRSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRSF1-to-partner and partner-to-GRSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by GRSF1-low versus GRSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRSF1→partner) and Y-score (partner→GRSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.678	+2.502	.001	.002	3	2
UCEC	ASNS →	+0.378	+2.584	.007	.010	3	2
UCEC	c-Jun_pS73 →	-0.128	-3.312	.040	.010	3	2
UCEC	EGFR_pY1068 →	-0.281	-3.459	.004	.005	3	1
UCEC	EGFR →	-0.158	-1.584	.011	.036	3	1
UCEC	eIF4E →	+0.179	+3.335	.030	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by GRSF1 expression — UCEC

Explore this box plot interactively →