GRPR

Across TCGA pan-cancer cohorts, GRPR Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GRPR data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GRPR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRPR expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

HNSC, BLCA, and LUAD are the cancer types where GRPR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.156	0.711	.007	18	view →
BLCA	DFS	Median	All	0.163	0.625	.018	9	view →
LUAD	DFS	Median	II,III,IV	1.000	0.223	.017	7	view →
OV	OS	Median	III,IV	1.000	0.310	.045	6	view →
LIHC	DFS	Median	All	0.096	0.543	.028	6	view →
LGG	OS	Median	All	0.317	0.799	.015	3	view →
COAD	OS	Median	All	0.648	0.874	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GRPR–HNSC (OS)

Open the HNSC breakdown →