GRPR

Across TCGA patient cohorts, GRPR mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRPR-associated genes across cancer lineages are eIF4G, JNK2, and Ku80. Each is linked with GRPR in more than 1 cancer types. Because this analysis shows association rather than direction, both GRPR-to-partner and partner-to-GRPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by GRPR-low versus GRPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRPR→partner) and Y-score (partner→GRPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.281	+2.115	.038	.019	3	1
UCEC	JNK2 →	+0.234	+3.026	.006	.018	3	1
UCEC	Ku80 →	+0.216	+1.598	.036	.044	3	1
UCEC	MEK1 →	+0.379	+3.584	.017	.002	3	1
UCEC	Rab11 →	-0.163	-3.321	.010	.009	3	1
UCEC	S6_pS240_S244 →	+0.536	+2.459	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4G by GRPR expression — UCEC

Explore this box plot interactively →