Across TCGA pan-cancer cohorts, GRPEL2P2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of GRPEL2P2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where GRPEL2P2 RNA is repressed in tumor relative to normal tissue. In most cancer types GRPEL2P2 is over-expressed in tumor, although a few such as BRCA and STAD show the opposite, repressed pattern.
BRCA, COAD, and STAD are the cancer types where GRPEL2P2 tumor–normal differential expression is most reproducible.