GRPEL2-AS1

Across TCGA pan-cancer cohorts, GRPEL2-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated GRPEL2-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher GRPEL2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRPEL2-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

THCA, UVM, and COAD are the cancer types where GRPEL2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Quartile	III,IV	0.536	0.884	.001	62	view →
UVM	DFS	Median	III,IV	0.333	0.739	.001	39	view →
COAD	DFS	Tertile	II,III,IV	0.336	0.717	<.001	35	view →
KIRP	DFS	Median	IV	0.042	0.591	.003	31	view →
MESO	OS	Tertile	All	0.265	0.447	.011	23	view →
SKCM	OS	Median	IV	0.867	0.225	.001	14	view →
HNSC	OS	Quartile	IV	0.844	0.645	.006	13	view →
ESCA	OS	Quartile	All	0.536	0.780	.014	12	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	12	view →
KIRC	DFS	Median	II,III,IV	0.430	0.595	.008	11	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	10	view →
LGG	DFS	Tertile	All	0.742	0.892	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GRPEL2-AS1–THCA (DFS)

Open the THCA breakdown →