GRPEL1

Across TCGA pan-cancer cohorts, GRPEL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GRPEL1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GRPEL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRPEL1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where GRPEL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.605	0.914	<.001	37	view →
PDAC	OS	Tertile	II,III,IV	0.794	0.881	.001	25	view →
LUAD	DFS	Median	II,III,IV	0.984	0.690	.008	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.828	.026	6	view →
GBM	DFS	Tertile	All	0.492	0.217	.014	6	view →
HNSC	DFS	Median	IV	0.809	0.555	.009	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GRPEL1–CCRCC (DFS)

Open the CCRCC breakdown →