GRPEL1

Across TCGA patient cohorts, GRPEL1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRPEL1-associated genes across cancer lineages are VHL, ATM, and NF-kB-p65_pS536. Each is linked with GRPEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRPEL1-to-partner and partner-to-GRPEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GRPEL1-low versus GRPEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRPEL1→partner) and Y-score (partner→GRPEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.083	-3.169	.003	.020	3	1
UCEC	ATM →	-0.523	-3.169	.035	.020	3	1
UCEC	NF-kB-p65_pS536 →	-0.565	-2.990	.023	.036	2	1
UCEC	c-Kit →	-0.252	-3.169	.049	.020	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VHL by GRPEL1 expression — UCEC

Explore this box plot interactively →