GRN

Across TCGA pan-cancer cohorts, GRN Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GRN data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GRN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRN expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

HNSC, BLCA, and UCEC are the cancer types where GRN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.115	0.733	<.001	12	view →
BLCA	DFS	Median	II,III,IV	1.000	0.607	.030	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	III,IV	0.019	0.698	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GRN–HNSC (OS)

Open the HNSC breakdown →