GRN

Across TCGA patient cohorts, GRN protein abundance is significantly associated with the RNA expression of many other genes, with 8,553 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GRN-associated genes across cancer lineages are KLHL23, PILRA, and DOK3. Each is linked with GRN in more than 5 cancer types. Because this analysis shows association rather than direction, both GRN-to-partner and partner-to-GRN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRN versus KLHL23 in HNSC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRN→partner) and Y-score (partner→GRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLHL23 →	-1.194	-0.415	<.001	<.001	3	5
COAD	PILRA →	+0.795	+0.376	.001	<.001	2	6
GBM	DOK3 →	+0.586	+0.777	.002	.002	3	5
GBM	ABCA1 →	+0.633	+0.945	<.001	<.001	3	5
COAD	LILRB3 →	+0.839	+0.346	<.001	.003	3	5
COAD	FAM20A →	+0.723	+0.432	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,553 associations by consensus.

GRN vs KLHL23 — HNSC

Explore this scatter interactively →