GRN

Across TCGA patient cohorts, GRN mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRN-associated genes across cancer lineages are eIF4E, GAPDH, and mTOR_pS2448. Each is linked with GRN in more than 2 cancer types. Because this analysis shows association rather than direction, both GRN-to-partner and partner-to-GRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GRN-low versus GRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRN→partner) and Y-score (partner→GRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+2.321	.036	.034	3	3
COAD	GAPDH →	+0.802	+3.008	.002	.019	3	2
COAD	mTOR_pS2448 →	-0.213	-2.991	.021	.036	2	3
COAD	ATM →	-0.594	-2.991	.003	.036	3	2
UCEC	eEF2 →	+0.357	+2.999	.015	.035	3	2
UCEC	MEK1 →	+0.490	+2.584	.001	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by GRN expression — UCEC

Explore this box plot interactively →