GRN

Across TCGA cell cohorts, GRN RNA expression is significantly associated with the go_rna of many other GO terms, with 6,002 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GRN-associated GO terms across cancer lineages are Negative regulation of respiratory burst involved in inflammatory response, Negative regulation of respiratory burst, and Viral process. Each is linked with GRN in more than 19 cancer types. Because this analysis shows association rather than direction, both GRN-to-partner and partner-to-GRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of respiratory burst involved in inflammatory response grouped by GRN-low versus GRN-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRN→partner) and Y-score (partner→GRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.160	+1.830	<.001	<.001	3	20
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.160	+1.830	<.001	<.001	3	20
BONE	Viral process →	+0.112	+1.687	<.001	<.001	3	15
STOMACH	Macroautophagy →	+0.079	+1.158	.003	.001	3	15
LUNG_SCLC	Membrane protein proteolysis →	+0.127	+1.472	<.001	<.001	3	15
LUNG_SCLC	Regulation of respiratory burst involved in inflammatory response →	+0.197	+0.825	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,002 associations by consensus.

Negative regulation of respiratory burst involved in inflammatory response by GRN expression — BLOOD_Lymphoma

Explore this box plot interactively →