GRN

Across TCGA cell cohorts, GRN mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRN-associated genes across cancer lineages are SMIM9, OR1E3, and CT47A6. Each is linked with GRN in more than 1 cancer types. Because this analysis shows association rather than direction, both GRN-to-partner and partner-to-GRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM9 grouped by GRN-low versus GRN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRN→partner) and Y-score (partner→GRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SMIM9 →	+0.110	+4.867	.002	.009	3	1
STOMACH	OR1E3 →	+0.187	+4.285	<.001	.007	3	1
STOMACH	CT47A6 →	+0.035	+4.285	<.001	.007	3	1
BLOOD_Leukemia	WFDC11 →	+0.041	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GALP →	+0.058	+5.201	<.001	.006	3	1
BLOOD_Leukemia	ARSH →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SMIM9 by GRN expression — BLOOD_Lymphoma

Explore this box plot interactively →