Across TCGA patient cohorts, GRM7 mutation is significantly associated with the RNA expression of many other genes, with 7,664 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM7-associated genes across cancer lineages are NCBP3, EPHB6, and NARF. Each is linked with GRM7 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRM7-to-partner and partner-to-GRM7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM7→partner) and Y-score (partner→GRM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCBP3 →	+0.354	+2.423	.002	.001	3	5
LUAD	EPHB6 →	-0.732	-3.906	<.001	<.001	3	4
LUAD	NARF →	+0.352	+3.816	.001	<.001	3	4
LUAD	THRB →	-0.525	-1.830	.002	.008	3	4
LUAD	PLD4 →	-0.553	-3.169	.001	<.001	3	4
HNSC	ZNF692 →	+0.617	+2.807	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,664 associations by consensus.

Exploration

GRM7 survival (RNA) · tumor vs normal (RNA) · all GRM7 data types