Across TCGA patient cohorts, GRM7 mutation is significantly associated with the total protein of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM7-associated genes across cancer lineages are Stathmin, p38-MAPK, and TIGAR. Each is linked with GRM7 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM7-to-partner and partner-to-GRM7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM7→partner) and Y-score (partner→GRM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Stathmin →	+0.157	+2.597	.001	.005	3	4
BLCA	p38-MAPK →	-0.206	-2.987	.030	.035	3	3
LUSC	TIGAR →	+0.195	+2.746	<.001	.002	3	3
COAD	E-Cadherin →	-0.677	-1.700	<.001	.040	3	3
COAD	Akt →	-0.559	-2.115	<.001	.017	3	3
COAD	Caspase-7-cleavedD198 →	+0.882	+1.934	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

Exploration

GRM7 survival (RNA) · tumor vs normal (RNA) · all GRM7 data types