GRM6

Across TCGA pan-cancer cohorts, GRM6 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GRM6 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRM6 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRM6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUSC, and LUAD are the cancer types where GRM6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.941	0.431	.009	26	view →
LUSC	DFS	Median	II,III,IV	0.506	0.724	.006	17	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
SKCM	OS	Median	III,IV	1.000	0.797	.014	7	view →
KIRP	DFS	Median	All	0.181	0.768	.004	6	view →
GBM	DFS	Median	All	0.048	0.242	.006	3	view →
COAD	OS	Median	All	0.291	0.706	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GRM6–UCEC (DFS)

Open the UCEC breakdown →