GRM6

Across TCGA patient cohorts, GRM6 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM6-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with GRM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRM6-to-partner and partner-to-GRM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GRM6-low versus GRM6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM6→partner) and Y-score (partner→GRM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR_pS2448 →	-0.163	-3.304	.010	.009	3	3
COAD	Caspase-7-cleavedD198 →	+0.956	+2.717	<.001	.002	3	3
UCEC	4E-BP1 →	+0.290	+3.999	<.001	<.001	3	3
UCEC	MEK1 →	+0.439	+2.584	<.001	<.001	3	3
UCEC	p27_pT157 →	-0.043	-1.463	.014	.028	3	3
UCEC	Shc_pY317 →	-0.096	-1.125	.036	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

mTOR_pS2448 by GRM6 expression — COAD

Explore this box plot interactively →