GRM6

Across TCGA cell cohorts, GRM6 mutation is significantly associated with the RNA expression of many other genes, with 1,287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM6-associated genes across cancer lineages are RPS9, RPL18A, and GAR1. Each is linked with GRM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRM6-to-partner and partner-to-GRM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS9 grouped by GRM6-low versus GRM6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM6→partner) and Y-score (partner→GRM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPS9 →	+0.421	+3.082	.001	.007	3	3
LARGE_INTESTINE	RPL18A →	+0.375	+2.351	.006	.001	3	2
LARGE_INTESTINE	GAR1 →	+0.526	+2.502	<.001	.002	3	2
LARGE_INTESTINE	QPCT →	-1.628	-2.093	.002	.004	3	2
LARGE_INTESTINE	MYO5C →	+0.770	+3.459	.006	<.001	3	2
LARGE_INTESTINE	CCDC62 →	+0.231	+2.351	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,287 associations by consensus.

RPS9 by GRM6 expression — LARGE_INTESTINE

Explore this box plot interactively →