GRM6

Across TCGA cell cohorts, GRM6 mutation is significantly associated with the mutation status of many other genes, with 6,003 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM6-associated genes across cancer lineages are NPC1L1, ZNF835, and ADCY1. Each is linked with GRM6 in more than 5 cancer types. Because this analysis shows association rather than direction, both GRM6-to-partner and partner-to-GRM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPC1L1 grouped by GRM6-low versus GRM6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM6→partner) and Y-score (partner→GRM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NPC1L1 →	+3.115	+3.784	.001	.001	1	6
LUNG_NSCLC_LUAD	ZNF835 →	+3.604	+2.718	.003	.003	1	5
BLOOD_Leukemia	ADCY1 →	+3.341	+3.341	.001	.001	1	5
BLOOD_Leukemia	NPAP1 →	+2.341	+2.638	.009	.009	1	5
SKIN	RALGAPA2 →	+3.148	+3.148	<.001	<.001	1	5
LARGE_INTESTINE	TRERF1 →	+1.947	+1.807	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,003 associations by consensus.

NPC1L1 by GRM6 expression — LUNG_SCLC

Explore this box plot interactively →