GRM5

Across TCGA patient cohorts, GRM5 mutation is significantly associated with the RNA expression of many other genes, with 7,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM5-associated genes across cancer lineages are PFKFB4, APCDD1, and FEN1. Each is linked with GRM5 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRM5-to-partner and partner-to-GRM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFKFB4 grouped by GRM5-low versus GRM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM5→partner) and Y-score (partner→GRM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFKFB4 →	+0.543	+1.866	<.001	<.001	3	5
COAD	APCDD1 →	-1.227	-2.584	<.001	<.001	3	5
UCEC	FEN1 →	+0.721	+2.102	<.001	<.001	3	5
STAD	DEPDC1 →	+0.591	+2.347	.004	.002	3	5
STAD	GRPEL1 →	+0.452	+2.247	<.001	.001	3	5
UCEC	PDHX →	+0.384	+1.649	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,211 associations by consensus.

PFKFB4 by GRM5 expression — UCEC

Explore this box plot interactively →