GRM5

Across TCGA cell cohorts, GRM5 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM5-associated genes across cancer lineages are CTCFL, H4C12, and H2BC3. Each is linked with GRM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRM5-to-partner and partner-to-GRM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTCFL grouped by GRM5-low versus GRM5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM5→partner) and Y-score (partner→GRM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CTCFL →	+0.927	+3.067	.009	.009	3	2
SKIN	H4C12 →	+0.816	+2.688	.001	.002	3	2
SKIN	H2BC3 →	+0.347	+2.849	<.001	.003	3	2
BLOOD_Lymphoma	C1orf146 →	+0.074	+4.781	<.001	<.001	3	2
BLOOD_Leukemia	IQCA1L →	+0.095	+2.505	<.001	.004	3	2
LUNG_NSCLC_LUSC	PLAAT5 →	+0.092	+3.678	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

CTCFL by GRM5 expression — SKIN

Explore this box plot interactively →