GRM4

Across TCGA patient cohorts, GRM4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,004 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GRM4-associated genes across cancer lineages are YPEL1, PRODH, and SEZ6L. Each is linked with GRM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRM4-to-partner and partner-to-GRM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRM4 versus YPEL1 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM4→partner) and Y-score (partner→GRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.703	+0.750	.001	.004	3	1
GBM	PRODH →	+0.915	+0.827	.002	<.001	3	1
GBM	SEZ6L →	+1.418	+0.695	.002	.005	3	1
GBM	SEPTIN3 →	+1.300	+0.815	<.001	<.001	3	1
GBM	NEFH →	+1.386	+0.591	<.001	.002	3	1
GBM	SYNGR1 →	+1.023	+0.802	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,004 associations by consensus.

GRM4 vs YPEL1 — GBM

Explore this scatter interactively →