GRM4

Across TCGA patient cohorts, GRM4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM4-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and TIGAR. Each is linked with GRM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM4-to-partner and partner-to-GRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GRM4-low versus GRM4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM4→partner) and Y-score (partner→GRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.210	+3.016	<.001	.018	3	4
UCEC	Cyclin-B1 →	+0.411	+1.169	.010	.017	3	4
STAD	TIGAR →	+0.391	+2.321	.034	.034	3	3
UCEC	GAPDH →	+0.408	+1.514	.008	.012	3	3
UCEC	mTOR_pS2448 →	-0.125	-1.347	.003	.006	3	3
UCEC	ATM →	-0.551	-2.308	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by GRM4 expression — COAD

Explore this box plot interactively →